Kidney Inflammation, Injury and Regeneration 2020

• Other Authors: Baer, Patrick C. (Editor), Koch, Benjamin (Editor), Geiger, Helmut (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; inflammation; chronic kidney disease; anemia; anemia of inflammation; ESA hyporesponsiveness; renal tubular epithelial cells; macrophages; lipocalin-2; iron; cilastatin; hypoxia inducible factor-1-α; ischemia-reperfusion injury; acute kidney injury; cyclophilin A; fibrosis; renal fibrosis; tubular necrosis; preeclampsia; podocytes; VEGF; FSGS; proteinuria; endocan; ESM-1; renal replacement therapy; kidney transplantation; biomarker; diabetic nephropathy; focal segmental glomerulosclerosis; innate immunity; membranous nephropathy; minimal change diseases; TLR; NOX1; ML171; reactive oxygen species; ERK; T cells; glomerulonephritis; chemokines; renal disease; DJ-1; ND-13; renal inflammation; oxidative stress; UUO; autophagy; apoptosis; trehalose; simvastatin; endotoxin; tubular apoptosis; cytochrome C; Bcl-XL; survivin; hypercholesterolemia; xanthine oxidase; NF-κB pathway; tertiary lymphoid organs; B cells; BAFF; kidney fibrosis; myofibroblast activation; extracellular matrix; Hippo pathway; verteporfin; IgAN; CKD; progression; ACEI; corticosteroids; costimulation; coinhibition; kidney transplant; SPR; protein binding affinity; adaptive immunity; epithelial-to-mesenchymal transition; E. cava extracts; dieckol; spontaneously hypertensive rats; angiotensin II; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function-in both the short- and long-term-is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.