Bacillus thuringiensis Toxins: Functional Characterization and Mechanism of Action

• Other Authors: Bel, Yolanda (Editor), Ferré, Juan (Editor), Hernández-Martínez, Patricia (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Bacillus thuringiensis; Plutella xylostella; Cry1Ac resistance; trypsin-like midgut protease; protoxin activation; Spodoptera spp., Helicoverpa armigera; Mamestra brassicae; Anticarsia gemmatalis; Ostrinia furnacalis; Cry2Ab toxin; Bombyx mori; ATP-binding cassette subfamily a member 2 (ABCA2); genome editing; transcription activator-like effector-nucleases (TALENs); HEK293T cell; functional receptor; Vip3Aa; lysosome; mitochondria; apoptosis; Sf9 cells; Cry1Ab; oligomer formation; Sf21 cell line; Ostrinia nubilalis; Lobesia botrana; Leptinotarsa decemlineata; bioassay; Cyt2Aa2 toxin; protein-lipid binding; erythrocyte membrane; AFM; QCM-D; Asian corn borer; ABCC2; CRISPR/Cas9; Cry1Fa; resistance; chitin-binding protein; adhesion; peritrophic matrix; Vip3A; Spodoptera litura; site-directed mutagenesis; Cry; Cyt; parasporins; S-layer proteins; Vip; Sip; membrane receptors; insecticidal activity; anticancer activity; Aedes aegypti; minor proteins; synergy; mosquito control; Bti; Spodoptera frugiperda; cadherin; mode of action of Cry toxin; insecticidal proteins; insect resistance; tobacco budworm; Bacillus thuringiensis proteins; coleopteran pests; structure; mode of action; 3D-structure; biological control; antimicrobial peptide; gut microbiota; vegetative insecticidal proteins; pyramids; 3D-Cry toxins; in vitro evolution; rational design; toxin enhancement; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Bacillus thuringiensis (Bt)-based products are the most successful microbial insecticides to date. This entomopathogenic bacterium produces different kinds of proteins whose specific toxicity has been shown against a wide range of insect orders, nematodes, mites, protozoa, and human cancer cells. So...