Drug Absorption Studies: In Situ, In Vitro and In Silico Models

Drug Absorption Studies: In Situ, In Vitro and In Silico Models

This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorpt...

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Bibliographic Details
Other Authors: Song, Im-Sook (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:
Medicine
Pharmaceutical industries
rebamipide
nanocrystals
oral mucositis
hydrogel
endocytosis
enoxaparin
lipid-polymer hybrid nanoparticles
oral
intestinal absorption
naftidrofuryl oxalate
solubility
permeability
dissolution profiles
pharmaceutical availability
BCS drug classification
non-sink condition
solubility-permeability interplay
unstirred water layer
poorly soluble drugs
solubilizer additive
phenylketonuria
l-phenylalanine ammonia-lyase
enzyme
kinetics
catabolism disorder
biomedical drug
P-glycoprotein
breast cancer resistance protein
LY335979
WK-X-34
in vivo-in vitro correlation
lipolysis-permeation
lipid-based drug delivery system
PermeaPad
cinnarizine
lipolysis
amorphous solid dispersion
candesartan Cilexetil
PVPK30
pH-modulation
spray drying
bioavailability
nasal administration
spray-drying
chitosan
microsphere
meloxicam
silymarin
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)
liver distribution
acetaminophen-induced hepatotoxicity
extra virgin olive oil
secoiridoids
metabolism
phenolic compounds
intestinal permeability
drug-phytochemical interaction
hepatic metabolism
mixed inhibition
quercetin
repaglinide
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Description
Summary:This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.
Physical Description:1 electronic resource (171 p.)
ISBN:books978-3-0365-2460-3
9783036524610
9783036524603
Access:Open Access

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