The Latest Clinical Advances in Thrombocytopenia

• Other Authors: ten Cate, Hugo (Editor), Lammle, Bernhard (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; thrombotic thrombocytopenic purpura; depression; resilience; quality of life; inherited thrombocytopenias; platelets; bleeding; TTP; ADAMTS13; treatment; diagnosis; follow-up; review; caplacizumab; pseudothrombocytopenia; hematimetry; fluorescence; amikacin; anticoagulants; COVID-19; platelet; thrombocytopenia; cardiac surgery; inflammation; biological prosthesis; extracorporeal life support; heparin-induced thrombocytopenia (HIT); new concepts; pathogenesis; management; immune PF4/heparin/antibody complexes; Bayesian diagnostic thinking; therapeutic plasma exchange; intravenous immunoglobulins (IVIG); immune thrombocytopenia; platelet destruction; immune tolerance; megakaryocytes; ITP treatment; virus infection; thrombocytopathy; aggregation; HIV; SARS-CoV-2; hantavirus; coronavirus; influenza; platelet disorders; procoagulant platelets; activation endpoints; myelodysplastic syndromes (MDS); bone marrow failure (BMF) syndromes; aplastic anemia (AA); next-generation sequencing (NGS); platelet function tests; platelet count; flow cytometry; anticoagulation; antifibrinolytic; antiplatelet; cancer; thrombopoietin receptor agonist; tranexamic acid; advanced liver disease; bleeding risk; cirrhosis; hemostasis; thrombopoietin receptor agonists/mimetics; platelet transfusion guidelines; platelet transfusion alternatives; platelet additive solutions; platelet pathogen inactivation/reduction; cold stored platelet concentrates; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Platelets are critical elements in the blood stream, supporting hemostasis (defense against bleeding), as well as performing even more complex tasks within networks of biological (immunity) and pathophysiological processes, such as cancer and ischemia/reperfusion injury. Changes in the number (and function) of platelets may have a substantial impact on any of these processes. The "simple" finding of a reduced platelet count (thrombocytopenia) has a history (origin) and a consequence (e.g., bleeding). This book brings together international experts to provide an up-to-date overview of the impact of thrombocytopenia from a clinical perspective.