Arteriogenesis and Therapeutic Angiogenesis

• Other Authors: Quax, Paul (Editor), Deindl, Elisabeth (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; angiogenesis; vessel maturity; vessel permeability; hemorrhage; atherosclerosis; two-photon intravital microscopy; transforming growth factor-β; endoglin; neovascularization; tissue repair; myocardial infarction; hind limb ischemia; critical limb ischemia; arteriogenesis; cell therapy; secretomes; AP-1 transcription factors; JunB; tip cell specification; vascular development; neurovascular interactions; peripheral arterial disease; biomarkers; inflammation; coagulation; extracellular vesicles; microRNAs; machine learning; gene therapy; stem cells; clinical trials; bioengineering; gene expression; non-viral vectors; 2A-peptides; growth factors; tube formation; VEGF; FGF2; cytokines; animal model; Matrigel plug assay; cold-inducible RNA-binding protein; extracellular cold-inducible RNA-binding protein; CIRP; eCIRP; neutrophil extracellular traps; NETs; macrophage polarization; apoptosis; ischemia; vascular smooth muscle cell; phenotypic switch; collateral arteries; C57BL/6J mice; SV-129 mice; leukocytes; macrophages; neutrophils; C57BL6; 129S1/Sv; CIRBP; 14q32 microRNAs; HUVECs; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.