Molecular and Cellular Mechanisms of Preeclampsia

• Other Authors: Huppertz, Berthold (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; Body mass index (BMI); cardiovascular/cerebrovascular diseases; cardiovascular risk; children; echocardiography; microRNA expression; pregnancy complications; prehypertension/hypertension; primary prevention; screening; preeclampsia; hematopoietic stem/progenitor cells; umbilical cord blood; erythropoiesis; Atg7; autophagy; lysosomes; placenta; protein aggregation; p62/SQSTM1; asymmetric dimethylarginine; nitric oxide; homocysteine; epigenetics; DNA methylation; non coding RNAs; miRNAs; histone post translational modifications; HOX genes; H19; miR-210; vagal withdrawal; baroreflex sensitivity; blunted cardiac response; cardiovascular adaptations; autonomic nervous system; Placental protein 13; Gal 10; Gal 13; Gal 14; Gal 16; FGR; polymorphism; risk prediction; biomarkers; eNOS; uterine artery; maternal cardiovascular system; monocyte; macrophage; decidua; inflammation; angiogenesis; highly active anti-retroviral therapy; human immunodeficiency virus; lymphangiogenesis; immune response; micro-bleeds; cerebral cytokines; microglia; pregnancy; placentation; low dose aspirin; exosomes; hypertensive disorders of pregnancy; RAGE; AGE; adipocyte; IL-6; CCL2; LPS; RARRES; chemerin; IUGR; PE; eNOS-knockout; CmklR1; IL-11; low protein diet; trophoblast; invasion; uterine glands; uterine milk; intra-uterine growth restriction; pregnancy outcome; placental bioenergetics 1; phosphocreatine 2; metabolism 3; obstetrics 4; speckle tracking echocardiography; cardiovascular dysfunction; animal models of human disease; placental insufficiency; inflammasomes; hydroxychloroquine; sFlt-1; sEng; TNF-α; endothelial dysfunction; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

This Special Issue on the "Molecular and Cellular Mechanisms of Preeclampsia" belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics" of the International Journal of Molecular Sciences. It was a very successful Special Issue as it contains 20 published papers, including one editorial, nine original research papers, and ten reviews on the topic. The original publications cover a wide spectrum of topics, including alterations and involvement of specific factors during preeclampsia, new non-invasive technologies to identify changes, new treatment options, animal models, gender aspects, and effects of the pregnancy pathology later in life. The review publications again cover a wide spectrum of topics, including factors and pathways involved in preeclampsia, effects on the maternal vascular and immune systems, effects on the placenta and the trophoblast, epigenetic changes, new preventive strategies, and new views on the current hypotheses on preeclampsia. Taken together, this Special Issue gives a fantastic overview on a broad spectrum of topics, all of which are important to identify the real etiology of preeclampsia and to finally develop real treatment options.