Endometriosis Research From Bench to Bedside

• Other Authors: Laganà, Antonio Simone (Editor), La Rosa, Valentina Lucia (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; BTG1; endometriosis; human endometrial stromal cells; endometrium; uterus; purinergic signaling; ATP; pathogenesis; genetics; epigenetics; immunology; ion channels; etiology; CFTR; aquaporin; chloride channels; biomarker; angiogenesis; cytokines; urinary biomarkers; genetic polymorphisms; SNPs; aetiology; Mediterranean population; Sardinian population; peritoneal fluid; microenvironment; precision medicine
• Online Access: DOAB: download the publication; DOAB: description of the publication

Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%-10% of women of reproductive age, to 50% of infertile women. Its etiopathogenesis of endometriosis still remains controversial-immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.This book aims to summarize recent ground-breaking studies that may open new scenarios and change the perspective of the topic, including cutting-edge elements about diagnosis, pharmacologic and surgical treatments, as well as basic/translational science (immunology, cell biology, genetics, and epigenetics) pieces of evidence, to unravel new pathways to follow for the future diagnosis and management of endometriosis, and to improve our current knowledge of its aetiology.