NASH and Systemic Complications From Basic to Clinical Research

• Other Authors: Shiri-Sverdlov, Ronit (Editor), Baumgartner, Sabine (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; NAFLD; mouse models; multifactorial disease; translational value; non-alcoholic fatty liver disease; steatohepatitis; NASH; cognitive impairment; memory dysfunction; Alzheimer's disease; neurodegeneration; liver stiffness; liver steatosis; controlled attenuation parameter; transient elastography; MRI PDFF; MR spectroscopy; non-alcoholic steatohepatitis (NASH); tunneling nanotubes (TNTs); primary hepatocytes; organelle transfer; mesenchymal stromal cells; aminopyrine; microsomal; liver function; breath test; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; extracellular vesicles; magnesium (Mg2+); obesity; insulin resistance (IR); type 2 diabetes mellitus (T2DM); hypertension; cardiovascular diseases (CVD); non-alcoholic steatohepatitis; intestinal permeability; microbiota; probiotics; physical exercise; fecal microbiota transplantation; hepatocellular carcinoma; pathogenesis; extra-hepatic outcome; organ-on-a-chip; artificial intelligence; liver disease; GLP-1 agonist; SGLT-2 inhibitor; type 2 diabetes; innate immune system; adaptive immune system; metabolic syndrome; fatty liver; leptin; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). NASH is a chronic inflammatory condition of the liver that can further progress to fibrosis and cirrhosis, which may eventually lead to liver failure and death. While we have increased our mechanistic knowledge regarding the pathogenesis of NASH within the last decade, treatment options are still limited and liver biopsies have remained the gold standard for diagnosis. To achieve major clinical breakthroughs for NASH patients, it is not sufficient to use a single animal model, since each model has specific limitations. Furthermore, we should rely more on alternative models such as organ-on-a-chip, which will enable us to explore unknown aspects of disease pathogenesis much faster and serve as clinically relevant surrogates for murine models. Another important direction for the improvement of patient health is to pay more attention to extrahepatic, organ-specific and systemic effects, which are associated with NASH. The articles in this Special Issue include an up-to-date overview of the rapidly developing technologies, novel targets for intervention and insights in the field in NASH. Additionally, these articles describe the major challenges in the field, strategies to overcome them and suggestions for future directions. To improve patient's outcome, clinicians, as well as scientists with biomedical, nutrition, physics and mathematics backgrounds, should join forces. Although challenges remain, the future of the field seems promising as these novel technologies and developments are expected to lead to progress in NASH.