Toxin and Immunotoxin Based Therapeutic Approaches

• Other Authors: Bortolotti, Massimo (Editor), Polito, Letizia (Editor), Bolognesi, Andrea (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Humanities; Social interaction; 3D structure; plant toxin; primary sequence; ribosome-inactivating protein; stenodactylin; toxic lectin; fusion proteins; ricin; pokeweed antiviral protein; COVID-19; SARS-CoV-2; antiviral agent; ribosome-inactivating proteins; monoclonal antibody; immunotoxin; antibody drug conjugate; immunoliposome; drug delivery; diphtheria toxin; DT3C; prostate cancer; targeted toxins; epidermal growth factor; epidermal growth factor receptor; Pseudomonas Exotoxin A; patient-derived glioblastoma cell lines; Chenopodium quinoa wild; quinoin; temozolomide; Glypican-3; hepatocellular carcinoma; humanized YP7; new recombinant immunotoxin; kirkiin; sugar specificity; cancer therapy; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

In 1900, Paul Ehrlich, who was studying ricin and abrin at the time, discovered antibodies and paved the way for immunotherapy. After 120 years, Ehrlich's insight into the therapeutic potential of immunotargeting is still a source of inspiration for many scientists. One of the most studied antibody-based targeting strategies is the carrying of powerful toxins. The generated molecules are immunotoxins, i.e., chimeric proteins obtained by coupling bacterial or plant toxins and antibodies through chemical linking or genetic engineering. Immunotoxins are functionally designed to eliminate the cells responsible for pathological conditions, and they find applications in several fields, ranging from cancer to immunological diseases or pain control. Despite the lack of specificity, even native toxins find clinical application, but the use of unconjugated toxins is limited to loco-regional treatments. A fundamental requirement for the medical application of toxins and their immunoconjugates is in-depth knowledge of their interaction with target cells in terms of binding, uptake, intracellular routing, and substrate specificity. This Special Issue focuses on toxins and immunotoxins that have clinical potential. We hope to give the reader a comprehensive overview of new toxin delivery strategies and toxin-based experimental disease models, both in vitro and in vivo.