The Effects of Mycotoxins on Human and Animal Health-a Special Focus on the Cellular and Molecular Mechanisms Responsible for Mycotoxin Toxicity

This Special Issue gathers original studies (eight articles and one review) that aim to improve our knowledge concerning mycotoxin toxicity. The most recent research concerning the impact of zearalenone (ZEA) and the immune response is presented in a review that aims to explore the immunotoxicity pr...

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Other Authors: Marin, Daniela Eliza (Editor), Taranu, Ionelia (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
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245 1 0 |a The Effects of Mycotoxins on Human and Animal Health-a Special Focus on the Cellular and Molecular Mechanisms Responsible for Mycotoxin Toxicity 
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520 |a This Special Issue gathers original studies (eight articles and one review) that aim to improve our knowledge concerning mycotoxin toxicity. The most recent research concerning the impact of zearalenone (ZEA) and the immune response is presented in a review that aims to explore the immunotoxicity produced by ZEA on different types of immune cells (phagocytes related to innate immunity and lymphocytes related to acquired immunity) as well as on immune organs, and also to identify the mechanism of action used by ZEA to modulate the immune response. The role of zearalenone in macrophage-mediated innate immunity after bacterial lipopolysaccharide (LPS) stimulation was the subject of another study, suggesting that the intake of ZEA-contaminated food might result in decreasing innate immunity. Another important study related to the co-exposure to mycotoxins and other food/feed contaminants showed that combining patulin with cadmium induces enhanced hepatotoxicity and nephrotoxicity both in vitro and in vivo, while the exposure to both deoxynivalenol and porcine circovirus has an additive effect on inflammatory cytokines by inducing the mRNA expression of interleukine-1 beta (IL-1β) and interleukine-6 (IL-6). The use of feed compounds rich in bioactive constituents for mitigating the mycotoxins effects in swine was the subject of other three studies herein, which have shown the efficacy of antioxidants from dietary grapeseed and sea buckthorn meal waste to decrease the toxicity of a diet contaminated with aflatoxin B1 or both aflatoxin B1 and ochratoxin A at the level of organs involved in the metabolism and excretion (liver and kidney), as well as at the level of secondary lymphoid organs (mesenteric lymph nodes). The use of different models (cell co-culture model, rat model) are recommended by another two studies in order to evaluate the ochratoxin A toxicity or for better prediction of the mycotoxins risk for human cancer. 
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650 7 |a Research & information: general  |2 bicssc 
650 7 |a Biology, life sciences  |2 bicssc 
650 7 |a Technology, engineering, agriculture  |2 bicssc 
653 |a aflatoxin B1 
653 |a grape seed meal 
653 |a mesenteric lymph nodes 
653 |a piglets 
653 |a antioxidant effect 
653 |a feed additives 
653 |a mycotoxins 
653 |a CYPs gene expression 
653 |a vimentin 
653 |a CD10 
653 |a MNF 116 
653 |a renal cell cancer 
653 |a urothelial cancer 
653 |a testicular cancer 
653 |a immunohistochemistry 
653 |a ochratoxin A 
653 |a cell culture 
653 |a energy metabolism 
653 |a apoptosis-necrosis balance 
653 |a mitochondria 
653 |a patulin 
653 |a cadmium 
653 |a synergistic toxicity 
653 |a oxidative stress 
653 |a JNK1 
653 |a p53 
653 |a zearalenone 
653 |a metabolites 
653 |a innate immunity 
653 |a cell immunity 
653 |a humoral immunity 
653 |a deoxynivalenol 
653 |a PCV2 
653 |a IL-1β 
653 |a IL-6 
653 |a MAPK 
653 |a mycotoxin 
653 |a NLRP3 inflammasome 
653 |a macrophages 
653 |a CYPs protein expression 
653 |a CYPs enzyme activity 
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