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Gastrointestinal Cancers and Personalized Medicine

Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50...

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Bibliographic Details
Other Authors: Mini, Enrico (Editor), Nobili, Stefania (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
Medicine
Pharmacology
neutrophil-to-lymphocyte ratio
lymphocyte-to-monocyte ratio
prognosis
rectal cancer
mesorectum
sphincter preserving
molecular oncology
precision medicine
colorectal cancer
targeted therapy
molecular profiling
pancreatic cysts
thermal liquid biopsy
differential scanning calorimetry
diagnosis
generalized linear models
gene signature
mRNA expression
VANGL1
FFPE
neurotoxicity
oxaliplatin
chemotherapy-induced peripheral neuropathy
biomarker
genomics
neuropathy
FOLFOX
FOLFIRINOX
XELOX
gastrointestinal cancer
LAG-3
immune checkpoint
colon cancer
survival
microsatellite instability
immunotherapy
n/a
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Description
Summary:Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to "personalized cancer medicine". Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.
Physical Description:1 electronic resource (136 p.)
ISBN:books978-3-0365-3807-5
9783036538082
9783036538075
Access:Open Access

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