The Role of PPARs in Disease

This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were publi...

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Bibliographic Details
Other Authors:	Wagner, Nicole (Editor), Wagner, Kay-Dietrich (Editor)
Format:	Electronic Book Chapter
Language:	English
Published:	Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:	Medicine Physiology peroxisome-proliferator activated receptors tumor angiogenesis tumor progression metastasis formation endothelial cells RNA sequencing PPARs toxicology pharmacology ligand vascular coronary artery lipidomics eicosanoids inflammation CYP450 peroxisome proliferator-activated receptor angiogenesis proliferation metastasis immortality resistance to cell death growth suppressors immune system cellular metabolism PPAR nuclear receptors addiction alcohol nicotine opioids psychostimulants animal models human studies Alzheimer's risk factors PPARα lipids fatty acids modulators cognition sex therapy hypertrophic adipocytes PPARG isoforms PPARG splicing dominant-negative isoform in vitro adipocytes adipogenesis hypertrophic obesity insulin-resistance peroxisome proliferator-activated receptors (PPARs) synthetic agonists non-alcoholic fatty liver disease (NAFLD) non-alcoholic steatohepatitis (NASH) fibrosis Sirtuin1 peroxisome proliferator-activated receptor-γ coactivator-1α peroxisome proliferator activated receptors obesity metabolic syndrome vitamin B12 folate fetal programming inherited metabolic disorders PGC-1α, disease kidney cancer AKI CKD nephron PKD cilia cystogenesis ligands Alzheimer's disease (AD)
Online Access:	DOAB: download the publication DOAB: description of the publication
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520			\|a This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.
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650		7	\|a Medicine \|2 bicssc
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653			\|a peroxisome-proliferator activated receptors
653			\|a tumor angiogenesis
653			\|a tumor progression
653			\|a metastasis formation
653			\|a endothelial cells
653			\|a RNA sequencing
653			\|a PPARs
653			\|a toxicology
653			\|a pharmacology
653			\|a ligand
653			\|a vascular
653			\|a coronary artery
653			\|a lipidomics
653			\|a eicosanoids
653			\|a inflammation
653			\|a CYP450
653			\|a peroxisome proliferator-activated receptor
653			\|a angiogenesis
653			\|a proliferation
653			\|a metastasis
653			\|a immortality
653			\|a resistance to cell death
653			\|a growth suppressors
653			\|a immune system
653			\|a cellular metabolism
653			\|a PPAR
653			\|a nuclear receptors
653			\|a addiction
653			\|a alcohol
653			\|a nicotine
653			\|a opioids
653			\|a psychostimulants
653			\|a animal models
653			\|a human studies
653			\|a Alzheimer's
653			\|a risk factors
653			\|a PPARα
653			\|a lipids
653			\|a fatty acids
653			\|a modulators
653			\|a cognition
653			\|a sex
653			\|a therapy
653			\|a hypertrophic adipocytes
653			\|a PPARG isoforms
653			\|a PPARG splicing
653			\|a dominant-negative isoform
653			\|a in vitro adipocytes
653			\|a adipogenesis
653			\|a hypertrophic obesity
653			\|a insulin-resistance
653			\|a peroxisome proliferator-activated receptors (PPARs)
653			\|a synthetic agonists
653			\|a non-alcoholic fatty liver disease (NAFLD)
653			\|a non-alcoholic steatohepatitis (NASH)
653			\|a fibrosis
653			\|a Sirtuin1
653			\|a peroxisome proliferator-activated receptor-γ coactivator-1α
653			\|a peroxisome proliferator activated receptors
653			\|a obesity
653			\|a metabolic syndrome
653			\|a vitamin B12
653			\|a folate
653			\|a fetal programming
653			\|a inherited metabolic disorders
653			\|a PGC-1α, disease
653			\|a kidney
653			\|a cancer
653			\|a AKI
653			\|a CKD
653			\|a nephron
653			\|a PKD
653			\|a cilia
653			\|a cystogenesis
653			\|a ligands
653			\|a Alzheimer's disease (AD)
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The Role of PPARs in Disease

MARC

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