Creatine Supplementation for Health and Clinical Diseases

• Other Authors: Kreider, Richard B. (Editor), Stout, Jeffrey (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; Food & society; ergogenic aids; cellular metabolism; phosphagens; sarcopenia; cognition; diabetes; creatine synthesis deficiencies; concussion; traumatic brain injury; spinal cord injury; muscle atrophy; rehabilitation; pregnancy; immunity; anti-inflammatory; antioxidant; anticancer; creatine; nutritional supplements; fertility; newborn; development; brain injury; post-viral fatigue syndrome; chronic fatigue syndrome; GAA; creatine kinase; dietary supplements; exercise; skeletal muscle; glycemic control; type 2 diabetes mellitus; phosphorylcreatine; dietary supplement; ergogenic aid; youth; athletes; osteoporosis; osteosarcopenia; frailty; cachexia; innate immunity; adaptive immunity; inflammation; macrophage polarization; cytotoxic T cells; toll-like receptors; vascular pathology; cardiovascular disease; oxidative stress; vascular health; female; menstrual cycle; hormones; exercise performance; menopause; mood; children; height; BMI-for-age; stature-for-age; growth; phosphocreatine; creatine transporter; supplementation; treatment; heart; heart failure; ischemia; myocardial infarction; anthracycline; cardiac toxicity; energy metabolism; cell survival; bioinformatics; systems biology; cellular allostasis; dynamic biosensor; pleiotropic effects of creatine (Cr) supplementation; inflammatory bowel diseases (IBD); ulcerative colitis; Crohn's disease; creatine kinase (CK); phosphocreatine (PCr); creatine transporter (CrT); intestinal epithelial cell protection; intestinal tissue protection; creatine perfusion; organ transplantation; Adenosine mono-phosphate (AMP); activated protein kinase (AMPK); liver kinase B1 (LKB1); mitochondrial permeability transition pore (mPTP); reactive oxygen species (ROS); glucose transporter (GLUT); T cell antitumor immunity; metabolic regulator; cancer immunotherapy; supplements; muscle damage; recovery; immobilization; atrophy; muscular dystrophy; amyotrophic lateral sclerosis; Parkinson's Disease; cardiopulmonary disease; mitochondrial cytopathy; hypertrophy; athletic performance; weightlifting; resistance exercise; training; muscular power; muscular adaptation; muscle fatigue; adipose tissue; muscle strength; physiological adaptation; mitochondria; thermogenesis; MAP kinase signaling system; sodium-chloride-dependent neurotransmitter symporters; signal transduction; intradialytic creatine supplementation; hemodialysis; muscle; protein energy wasting; clinical trial; muscle weakness; chronic fatigue; cognitive impairment; depression; anemia; resistance training; sports nutrition; strength; toxicity; methylation; hyperhomocysteinemia; neuromodulation; MCDA; mitochondriopathia; cardiac infarction; long COVID; hypoxia; stroke; neurodegenerative diseases; noncommunicable disease; adenosine 5'-monopnophosphate-activated protein kinase; anthracyclines; creatine supplementation; cardiac signaling; cardiotoxicity; doxorubicin; soy; vegetarian/vegan diet; amino acids; dietary ingredients; performance
• Online Access: DOAB: download the publication; DOAB: description of the publication

Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellul...