Targeting Wnt Signaling in Cancer: Opportunities Abound If We Can Avoid the Sword of Damocles

• Weitere Verfasser: Kahn, Michael (Herausgegeben von), Lai, Keane (Herausgegeben von)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Schlagworte: Medicine; Pharmacology; Wnt signaling; synovial sarcoma; TNIK; NCB-0846; MYC; hepatitis B virus; HBV; cancer; liver cancer; β-catenin; TCF/LEF; pancreatic cancer; pancreatic stellate cells; CBP; p300; pancreatitis; fibrosis; just-right signaling; APC; colorectal cancer; RNA-binding proteins; Musashi; drug discovery; Notch signaling; cancer therapy; fungi secondary metabolite derivative; microenvironment; Wnt; AML; drug target; signaling; colorectal; porcupine; R-spondin; serrated; immunotherapy; wnt; vitamin D; colon cancer; L1; Wnt target genes; cell adhesion; NF-κB; invasion and metastasis; cancer stem cells; EMT; Lgr5; Wnt/beta-catenin signaling; angiogenesis; anti-angiogenic therapy; gastrointestinal cancers; therapeutic targeting of Wnt signaling; β-catenin paradox; molecular targeting; urothelial cancer; immune checkpoint inhibitor; immunotherapy resistance; IBD; colitis; β-catenin mutations; tumor metabolism; tumor immunology; molecular therapeutics; precision medicine; astrocytic brain tumors; DKKs; GSK3β
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers w...