Purines as Transmitter Molecules: Electrophysiological Studies on Purinergic Signalling in Different Cell Systems
Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the...
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| Main Author: | |
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| Format: | Electronic Book Chapter |
| Language: | English |
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Firenze
Firenze University Press
2008
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| Series: | Premio Tesi di Dottorato
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| Subjects: | |
| Online Access: | DOAB: download the publication DOAB: description of the publication |
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| Summary: | Purinergic nucleotides and nucleosides (ATP, ADP, AMP and adenosine) are essential intracellular metabolites involved in a number of cellular processes, from energy supply to protein phosphorylation. However, in the last years, several studies demonstrated their involvement in cell signalling by the activation of specific membrane receptors (P1 and P2) and their role as neurotransmitters began to be investigated. The present work was aimed to clarify the effects of purinergic neurotransmission in different cell systems by using electrophysiological techniques. Relevant results of this research include the observation that P1 and P2 receptors play a deleterious role during "in vitro" ischemia in the rat brain, and the first demonstration of P2 receptor expression and function in a line of adult human mesenchymal stem cells. |
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| Physical Description: | 1 electronic resource (192 p.) |
| ISBN: | 978-88-8453-905-2 9788884539052 9788884539045 9788892737891 |
| Access: | Open Access |