PPARs as Key Mediators of Metabolic and Inflammatory Regulation

• Other Authors: Vázquez-Carrera, Manuel (Editor), Wahli, Walter (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; Biochemistry; nuclear receptor; gene transcription; inflammation; molecular docking; PPARβ/δ; lung; pulmonary artery; GW0742; GSK3787; docking; lipopolysaccharide (LPS); PPARγ ligand; coumarin; fluorescent ligand; screening; crystal structure; PPAR; atopic dermatitis; psoriasis; metabolic reprograming; glucose; fatty acids; mycobacteria; M. tuberculosis; M. leprae; PPARs; lipid droplets; metabolic alterations; hepatic damage; nuclear factors; pharmacological targets; AMPK; GDF15; insulin resistance; type 2 diabetes mellitus; peroxisome proliferator-activated receptor gamma (PPARγ); real-time PCR; ELISA; immunohistochemistry; signaling pathway; PPAR gamma; brain; neural stem cells; infection; neuroinflammation; HIV; Zika; cytomegalovirus; neurogenesis; microglia; liver damage; toll-like receptor 4; P2Y2 receptor; metabolic syndrome; resveratrol; quercetin; PPARα; peroxisome; β-oxidation; PPRE; ligand; coregulator; micronutrients; PPARα knockout; adipose tissue; browning; lipid metabolism; depression; PPARg; neuropathology; corticotropin releasing hormone; norepinephrine; subgenual prefrontal cortex; amygdala; nucleus accumbens; common carotid artery occlusion; electroretinography; fibroblast growth factor 21; pemafibrate; peroxisome proliferator-activated receptor alpha; retinal ischemia; skeletal muscle; substrate metabolism; nonalcoholic fatty liver disease (NAFLD); sex dimorphism; lipidomics; hepatic sex-biased gene expression; PPARγ; pulmonary arterial hypertension; TGFβ; vascular injury; proliferation; kidney fibrosis; pattern-recognition receptors; phagocytosis; nitric oxide synthase; fenofibrate; oleoylethanolamide; palmitoylethanolamide; cancer; immunity; obesity; diabetes; miRNA; DNA methylation; histone modification; peroxisome-proliferator-activated receptor; fatty acid oxidation; doping control; regulatory T cells; exercise; nuclear receptors; nutrigenomics; energy homeostasis; dairy animals; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); peroxisome proliferator-activated receptors (PPAR); bezafibrate; fenofibric acid; peroxisome proliferator-activated receptor; dual/pan agonist; X-ray crystallography; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotype...