Paradox Role of Oxidative Stress in Cancer State of the Art

• Other Authors: Domenicotti, Cinzia (Editor), Marengo, Barbara (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; Oncology; sonodynamic therapy; carbon doped titanium dioxide; sonosensitizers; ultrasound; cancer treatment; breast cancer treatment; radiotherapy; hematological malignancies; oxidative stress; lymphoma; leukemia; multiple myeloma; apoptosis; mitochondria; ultraviolet-C (UVC); withanolide; combined treatment; oral cancer; DNA damage; cancer therapy; immune system; Hypericum perforatum; hyperforin; reactive oxygen species; pH regulation; tumor prevention; tumor therapy; cancerogenesis; inflammatory signaling; natural compounds; pancreatic cancer; antitumor agents; coordination polymers; bioinorganic chemistry; cold atmospheric plasma; reactive oxygen and nitrogen species; nitrite; cancer stem cells; chemoresistance; glutathione; lipid peroxidation; ZEB-1; GPX4; ferroptosis; HO-1; Nrf2; cancer progression; patients; therapy; prognosis; biomarker; Eprenetapopt; Erastin; glutathione (GSH); SLC7A11; iron; NRF2; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy.

Physical Description

1 electronic resource (214 p.)

ISBN

books978-3-0365-4422-9
9783036544212
9783036544229

Access

Open Access