Antiphospholipid Syndrome Recent Advances in Clinical and Basic Aspects
Antiphospholipid syndrome (APS) is an acquired autoimmune disorder in which the immune system mistakenly produces antiphospholipid antibodies that attack tissues in the body. These antibodies can lead to the formation of blood clots in arteries and veins. During pregnancy, APS can also lead to misca...
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| Format: | Electronic Book Chapter |
| Language: | English |
| Published: |
IntechOpen
2022
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| Subjects: | |
| Online Access: | DOAB: download the publication DOAB: description of the publication |
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| Summary: | Antiphospholipid syndrome (APS) is an acquired autoimmune disorder in which the immune system mistakenly produces antiphospholipid antibodies that attack tissues in the body. These antibodies can lead to the formation of blood clots in arteries and veins. During pregnancy, APS can also lead to miscarriage and stillbirth. Classification criteria require a clinical event (i.e., thrombosis or pregnancy complication) and persistent positive blood test results at least three months apart that detect lupus anticoagulant, anti-cardiolipin antibodies, or anti-β2-glycoprotein-1 antibodies. This book addresses important clinical aspects of APS, including stroke and APS, obstetric manifestations of APS, and bleeding complications in APS. It also discusses the diagnostic utility of a novel autoantibody against β2-glycoprotein I/HLA class II complexes as a promising biomarker for APS. Finally, this book also reviews the latest findings in the field of extracellular vesicles in APS and provides explanations of their role in the pathogenesis of APS. |
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| Physical Description: | 1 electronic resource (142 p.) |
| ISBN: | intechopen.91508 9781839690549 9781839690532 9781839690556 |
| Access: | Open Access |