Mutagenesis and Mitochondrial-Associated Pathologies

• Other Authors: Fasullo, Michael (Editor), Catala, Angel (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: IntechOpen 2022
• Subjects: Medical genetics
• Online Access: DOAB: download the publication; DOAB: description of the publication

Reactive oxygen species (ROS) and DNA double-strand breaks can result from mitochondrial defects and external sources, such as ionizing radiation. If not repaired properly, pathogenic mutations are generated. Human diseases resulting from inherited mitochondrial defects manifest in organs that physi...