Advances in Antifungal Development: Discovery of New Drugs and Drug Repurposing

• Other Authors: Kim, Jong Heon (Editor), Cheng, Luisa W. (Editor), Land, Kirkwood (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Biology, life sciences; nanoparticles; fungi; drug delivery systems; marine; biological synthesis; myconanotechnology; canesten; clotrimazole; vulvovaginal; vaginitis; mycosis; candidosis; yeast infection; candida; candida albicans; vaginal health; anticandidal activity; indazole; pyrazole; 3-phenyl-1H-indazole; drug design; acetylsalicylic acid (ASA, aspirin); capsule; CAP64; Cryptococcus; membrane potential (ΔΨM); photodynamic treatment; photosensitiser; ultrastructure; drug repurposing; antifungals; repositioning; yeasts; emerging fungi; multidrug resistance; therapeutic alternatives; new targets; Candida auris; Aspergillus spp.; antifungal; beta-glucan; polycations; Galleria mellonella model; retinoids; Candida spp.; onychomycosis; Malassezia spp.; dermatophytes; microbiology; mycology; all-trans retinoic acid; Acanthamoeba; free-living ameba; Acanthamoeba keratitis; isavuconazonium sulfate; cyst; drug; drug discovery; drug targets; invasive aspergillosis treatment; invasive fungal infections; fission yeast; cell wall; β(1,3)-D-glucan synthase; antifungal drugs; echinocandin drugs; echinocandin resistance; Fks resistance hot spots; cytokinesis; septation; cell separation; cell integrity; cell lysis; sporotrichosis; Felis catus; quinones; hydrazones; zoonoses; host-directed drug therapy; azoles; polyenes; echinocandins; viral infections; azole; synergy; resistance; Candida; natural products; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

Physical Description

1 electronic resource (282 p.)

ISBN

books978-3-0365-4767-1
9783036547688
9783036547671

Access

Open Access