In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application

In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application

The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translationa...

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Bibliographic Details
Other Authors: Baiocchi, Marta (Editor), Zeuner, Ann (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
Research & information: general
Biology, life sciences
Microbiology (non-medical)
colorectal cancer
organoids
3D bioprinting
patient-derived xenograft
cancer-on-chip
drug combination
cancer stem cells
drug resistance
clinical trials
tumor-initiating cells
tumor heterogeneity
patient-derived cancer models
single-cell RNA-sequencing
tumor metabolism
transcriptional programs
tumor cell differentiation
immunotherapy
methods
chromosomal instability
DNA damage
targeted therapy
decitabine
colon cancer
DNA methylation
clinical translation study
machine learning
patient-derived tumor organoid
precision medicine
radiation response
rectal cancer
PDX model
CRC
mutation analysis
histological examination
animal models
in vitro culture
cancer stem cell methods
SATB2
colorectal carcinoma
prognosis
CDX2
circulating tumor cells
CTC cluster
size-based method
ScreenCell®
epithelial mesenchymal transition
hypoxia
HIF-1α
immunofluorescence analysis
sequential filtration
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Summary:The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC.
Physical Description:1 electronic resource (222 p.)
ISBN:books978-3-0365-3965-2
9783036539669
9783036539652
Access:Open Access

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