Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug Discovery

• Other Authors: Hussain, Hidayat (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Research & information: general; Chemistry; Organic chemistry; multi-component reaction; fusidic acid; TEMPO-conjugate; electron paramagnetic resonance (EPR) spectroscopy; caspase-3; incomptine A; sesquiterpene lactone; Decachaeta incompta; cytotoxic activity; iTRAQ; apoptosis; ROS production; violacein; hepatocellular carcinoma; proliferation; stemness; natural products; tumor microenvironment (TME); lung cancer; phytochemicals; botanical agents; steroidal alkaloids; solanidane alkaloids; demissidine; solanidine; flavonoids; coronavirus; SARS-CoV-2; SARS-CoV; MERS-CoV; anticancer activity; apoptosis resistance; ophiobolin A; polygodial; Wittig reaction; melanoma; tumor heterogeneity; pregnancy; anti-tumor peptides; in vitro model; medicinal herbs; cancer treatment; cancer stem cells; drug resistance; metastasis; RCE-4; PCD; ATG 4B; the Bcl-2-Beclin 1 complex; Sparticola junci; structure elucidation; ECD-TDDFT; COX inhibitory; molecular docking; antiproliferative; cytotoxic; Sepedonium ampullosporum; peptaibols; ampullosporin; glutamic acid methyl ester; solid-phase peptide synthesis; antifungal; anticancer; target identification; kaempferol; docking; DARTS; Src; breast cancer; butein; frondoside-A; STAT3; angiogenesis; invasion; viability; tumor growth; marine fungi; Cosmospora sp.; soudanone; Magnaporthe oryzae; co-culture; phytopathogen; molecular networking; metabolomics; bispecific antibody; Trypsiligase; click chemistry; biorthogonal chemistry; antibody engineering; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.

Physical Description

1 electronic resource (360 p.)

ISBN

books978-3-0365-4743-5
9783036547442
9783036547435

Access

Open Access