Precision Medicine in Solid Tumors

• Other Authors: Dey, Nandini (Editor), De, Pradip (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel 2022
• Subjects: Medicine; Oncology; pediatric tumors; tumor mutational burden; TMB; whole-exome sequencing; gene panel sequencing; immune checkpoint inhibitors; glioblastoma prognosis; overall survival; extent of resection; random forest; Decision tree; personalized precision oncology; circulating free DNA; liquid biopsy; epidermal growth factor receptor; tyrosine kinase inhibitor; osimertinib; comprehensive genomic profiling; molecular genotyping; intratumor heterogeneity; multiple biopsies; tumor evolution; clonality classification; strategic therapeutic intervention; thymoma; driver mutation; sequencing; molecular barcoding; EGFR mutation; EGFR-TKI; cfDNA; NGS; digital enrichment; next-generation sequencing; solid cancer; universal health-care system; precision medicine; presumed germline findings; clinical guideline; non-small cell lung cancer; outcome; adjuvant chemotherapy; anaplastic lymphoma receptor tyrosine kinase; HNSCC; ctDNA; tDNA; DDR genes; PARP inhibitors; new drug development; next-generation sequencing (NGS); open data; regulatory reform; tumor profiling test; triple-negative breast cancer (TNBC); breast cancer; targeted therapy; TNBC subtypes; immunotherapy; cancer; screening; smoking; electronic records; PD-L1; cancer-associated fibroblasts; resistance; chemotherapy; CTC; immunocytochemistry; parallel double-detection; laboratory-friendly; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

In the era of precision medicine, the use of molecularly targeted therapies in selected patients has led to a paradigm change in cancer treatment. Multiple studies have demonstrated the benefits of therapies that are chosen based on the molecular profile of the tumor and also from the liquid biopsy. With genomics' increasing ability, a routine transcriptomics analysis of advanced/metastatic cancers is now feasible in most cancer hospitals, including community cancer centers. This is an unprecedented shift in the management of cancers irrespective of their organ types, which not only improved the outcome but also opened several new avenues in research and practice, such as immune-check-point inhibitors, tumor-TME co-evolution in the development of resistance, longitudinal liquid biopsies, biomarkers screening and the management of electronic medical records.This book brings together these crucial areas of investigation. The research presented here attempts to address the current issues to provoke thoughts for the future. The future of precision medicine will have to embrace a shift from in vitro, in vivo/PDX models for the mechanistic study to a more functional test based on the scientific interrogation of genomic data, in the form of functional precision medicine. We will also have to combat the element of noise in the multitudes of data and impart the regulatory structure to make judicious use of the data. The expectations for functional precision medicine are high. We aspire to witness a tremendous improvement in patient outcomes, from better to best, down the road that will match the clinical guidelines.