Functional Nanomaterials in Biomedicine

• Other Authors: Chen, Wansong (Editor), Zhang, Jianhua (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medical equipment & techniques; tumor microenvironment; targeted therapy; nanoparticles; nano therapeutics; tumor imaging; cell membrane coated nanoparticle; atherosclerosis; thrombosis; diagnosis and therapy; cardiovascular disease; Fe-based nanoparticles; endosomal pH-responsive hyaluronate; CD44 receptor-mediated endocytosis; tumor therapy; Alzheimer disease's; amyloid-β; nanomaterials; photothermal therapy; photodynamic therapy; biomedical imaging; iodinated contrast media; X-ray computed tomography; organic nanoparticles; iodinated polymers; SARS-CoV-2 main protease; colorimetry; electrochemical impedance spectroscopy; gold nanoparticles; selenium; selenium nanoparticles; antioxidant activities; clean-up procedure; glutathione; Parkinson's disease; L-DOPA; curcumin; nanozyme; single-atom nanozyme; surface modification; ROS scavenging; antibacterial; electrostatic spinning; inorganic nanocrystals; polymer fibers; antimicrobial; biomedical; graphene; nanocomposites; multimodal imaging; phototherapy; theranostics; cancer; bacterial infection; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The great success of nanotechnology promotes a tremendous revolution in the biomedical field. Functional nanomaterials have been widely applied for the treatment of various diseases, such as cancer, bacterial infection, diabetes, inflammation, and neurodegenerative disorders. Various therapeutic nanoplatforms have been developed with therapeutic functions and intelligent properties. However, the development of nanomedicine suffers from several challenges prior to their clinical applications. For instance, disease detection in an early stage is a critical challenge for nanomedicine. It is difficult to detect disease markers (e.g., proteins, genes, or cancer circulating cells), so nanoprobes with high sensitivity and selectivity are required. Moreover, to overcome drug resistance, it is highly desirable to develop functional nanomedicines with the combination of multiple therapeutic modalities, such as chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, radiotherapy, starving therapy, and immunotherapy. Additionally, the stability and degradability of most nanomedicines in biofluids should be carefully evaluated before their administration to humans. This book provides researchers with the latest investigations and findings in this field.