Frontiers of Targeted Therapy and Predictors of Treatment Response in Systemic Sclerosis

• 第一著者: Herrington, Gaya (auth)
• その他の著者: Tomcik, Michal (編集者)
• フォーマット: 電子媒体 図書の章
• 言語: 英語
• 出版事項: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• 主題: Research & information: general; Biology, life sciences; heat shock protein 90; systemic sclerosis; established dermal fibrosis; treatment; pathogenesis; epigenetic mechanisms; miRNAs; calcinosis cutis; bisphosphonates; pamidronate; autoimmune connective tissue diseases; dermatomyositis; immune cells; anti-inflammatory; therapy; fibrosis; interleukin-6; Tocilizumab; pulmonary fibrosis; interstitial lung disease; progressive fibrosing interstitial lung disease; lung function; body mass index; clinical trial; metabolomics; LC-MS/MS; ion mobility; kynurenine pathway; urea cycle; lipids; gut dysbiosis; pulmonary arterial hypertension (PAH); biomarkers; miRNA; complement; myofibroblasts; macitentan; cough; pulmonary hypertension; predictors of treatment response; autoreactive B cells; autoantibodies; rituximab; aptamers; Seldeg; n/a; mixed connective tissue disease; systemic lupus erythematosus; Sjögren's syndrome; rheumatoid arthritis; idiopathic inflammatory myopathy; national delphi consensus
• オンライン･アクセス: DOAB: download the publication; DOAB: description of the publication

Systemic sclerosis (scleroderma) is an incurable connective tissue disease with an unclear etiology characterized by vasculopathy, dysregulation of the immune response, and progressive tissue fibrosis affecting the skin, lungs, digestive tract, heart, and kidneys. The collection of six original rese...