Genomic Analysis of Antibiotics Resistance in Pathogens

• Other Authors: Nogueira, Teresa V. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; Microbiology (non-medical); antimicrobial; drug resistance; pan-genome; multilocus sequence typing; nosocomial infections; MDR P. aeruginosa; titanium dioxide nanoparticles; biofilm; efflux pumps; quorum-sensing system; real-time polymerase chain reaction; MDR E. coli; ESBLs; MBLs; MAR index; Francisella tularensis; resazurin; DipA; PilD; tularemia; antibiotic; resistance; Acinetobacter baumannii; colistin; carbapenems; multidrug resistant; WGS; KPC-70; Klebsiella pneumoniae; ceftazidime/avibactam resistance; KPC-3; ST13; KPC-variant; hypermucoviscosity; hypervirulence; Portugal; comparative genomic analysis; CA-MRSA; EMRSA-15; PVL-positive; ST22; N. gonorrhoeae; fluoroquinolone; AMR; ciprofloxacin; Mycobacteroides abscessus; tigecycline; genetic determinants; WhiB7; SigH; RshA; antimicrobial resistance; hvKP; K2 capsule; ST14; fimbrial proteins; aerobactin; antibiotic resistance; virulence; plasmid; Integrative and Conjugative Element; co-selection; genomics; evolution; S. Infantis; multidrug-resistance; blaCTX-M-65; fosA3; heavy-metal resistance; pESI-like megaplasmid; whole-genome sequencing; ST213 worldwide strains; genomic databases; antibiotic resistance plasmids; Typhimurium; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

The emergence of antibiotic-resistant pathogens currently represents a serious threat to public health and the economy. Due to antibiotic treatments in humans and veterinary medicine, prophylactic use and environmental contamination, bacteria are today more frequently exposed to unnatural doses of antibiotics and their selective effect.Antibiotic resistance can be encoded on chromosomes, plasmids, or other mobile genetic elements in bacteria. It may also result from mutations that lead to changes in the affinity of antibiotics for their targets or in the ability of antibiotics to act on bacterial growth or death. Exposure of bacteria, bacterial populations, and microbial communities to antibiotics at different concentrations shapes their genomic dynamics, as does the mobilisation and spread of resistance determinants. It is, therefore, essential to understand the dynamics and mobilisation of genes encoding antibiotic resistance, in human, animal, plant, and environmental microbiomes, through genomic and metagenomic approaches and bioinformatics analyses.This Special Issue gathers research publications on the horizontal transfer of antibiotic-resistance genes, their dissemination and epidemiology, their association with bacterial virulence, between bacterial genotypes and their phenotypes, and other related research topics.

Physical Description

1 electronic resource (220 p.)

ISBN

books978-3-0365-6523-1
9783036565248
9783036565231

Access

Open Access