Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications

• Other Authors: Zicha, Josef (Editor), Vaněčková, Ivana (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Cardiovascular medicine; developmental origins of health and disease (DOHaD); gut microbiota; hypertension; short chain fatty acid; oxidative stress; probiotics; prebiotics; renin-angiotensin system; fibroblast growth factor-23; left ventricular hypertrophy; renin-angiotensin-aldosterone system; losartan; canrenone; Hyp mice; X-linked hypophosphatemia; hairless SHRM; cold acclimation; cardiac Cx43; extracellular matrix; thyroid hormones; SHR; sacubitril/valsartan; ARNI; ivabradine; remodelling; cardiac dysfunction; fibrosis; angiotensin II; angiotensin 1-7; knock-out; genome-editing; SHRSP; Dahl SS; foetal programming of hypertension; sympathetic neurotransmission; sympathetic innervation; vascular remodelling; foetal undernutrition; old SHR; antihypertensive therapy; blood pressure monitoring; LV hypertrophy; ECM markers; cardiac fibrosis; SHR-CRP; SGLT-2 inhibitor; gene expression; age; lipid metabolism; nitric oxide; l-NAME; rostral ventrolateral medulla; aging; reactive oxygen species; NADPH oxidase activator 1; mitochondria; chloride; calcium-activated chloride channel; Na+-K+-2Cl− cotransporter 1; TMEM16A; smooth muscle; fetal undernutrition programming; cross-fostering; lactation period; cardiovascular hypertrophy; adipose tissue browning; cardiovascular disease; catecholamines; liquid chromatography-tandem mass spectrometry; SGLT-2 inhibition; proteinuria; uninephrectomized salt-loaded; two-kidney; one-clip hypertension; fawn-hooded hypertensive rat; ApoE KO; apolipoprotein E knockout mice; atherosclerosis; Na,K-ATPase; TCTP; TCTP-overexpressing transgenic mice; translationally controlled tumor protein; TCTP-TG; experimental hypertension; bone; rats; taurine; magnesium; 24 h urine(24U); stroke-prone spontaneously hypertensive rat; young SHR; combination therapy; treatment effect; systolic blood pressure
• Online Access: DOAB: download the publication; DOAB: description of the publication

Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused o...