Hallmarks of Parkinson's Disease

• Other Authors: Alves Da Costa, Cristine (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; Neurosciences; Parkinson's disease; unfolded protein response; reticulum endoplasmic; genetics; alpha-synuclein; prion-like spreading; cell-to-cell transfer; neurodegeneration; mitochondrial dysfunction; PINK1; neurons; astrocytes; microglia; α-synuclein; exocytosis; lipids; membranes; Parkinson disease; SNARE complex; synapse; vesicle fusion; therapeutic target; protein quality control; mitochondrial quality control; ubiquitin; alpha-syn; mitophagy; Parkin; mito-Keima; mito-QC; mito-SRAI
• Online Access: DOAB: download the publication; DOAB: description of the publication

This book gathers a collection of review articles aiming to provide an update of the current knowledge on PD pathogenesis. It notably includes an overview of several key cellular dysfunctions underlying the etiology of Parkinson's disease, including ER stress, mitophagy and alpha-synuclein-link...