New Insights into the Pathogenesis and Therapies of IgA Nephropathy

• Other Authors: Suzuki, Hitoshi (Editor), Novak, Jan (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; obesity; mesangial matrix expansion; body mass index; IgA nephropathy; IgA Vasculitis; IgA Nephropathy; adults; children; presentation; physiopathology; genetics; prognosis; treatment; IgA; clinical trials; kidney mesangium; mouse model; aberrantly glycosylated IgA1; galactose-deficient IgA1; glycosylation of IgA1; biomarker; complement C3; O-glycosylation; IgA1; autoantibody; immune complex; complement; kidney; nephrology; IgA vasculitis; nephritis; kidney biopsy; plasma cells; CD38; renal pathology; urinary galactose-deficient IgA1; KM55; crescents; proteinuria; glomerular filtration rate; Oxford score; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a frequent cause of kidney failure. Better understanding of the pathogenesis of IgAN and the related genetic, immunological, and cellular susceptibility factors are needed to enable the development of effectiv...