Clinical Utility of Applying PGx and Deprescribing-Based Decision Support in Polypharmacy Future Perspectives

• Other Authors: Vermehren, Charlotte (Editor), Westergaard, Niels (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; Pharmaceutical industries; acute kidney injury; early biomarker; plasma neutrophil gelatinase-associated lipocalin; soluble urokinase plasminogen activator receptor; medication optimization; older patients; emergency department; multimorbidity; polypharmacy; potentially inappropriate medication use; older adults; prevalence; determinants; chronic; outpatient; 2019 Beers criteria; Ethiopia; pharmacogenomics; persons with diabetes; drug-drug interactions; drug-gene interactions; cytochrome P450; SLCO1B1; drug interaction checkers; adverse drug reactions; pharmacogenetics; personalized medicine; phenprocoumon; DOACs; bleeding; thromboembolism; HLA; drug hypersensitivity; abacavir; allopurinol; flucloxacillin; antiepileptic drugs; cost-effectiveness; shared medication record; medication reconciliation; drug information service; hospital pharmacy service; electronic prescribing; electronic medical record; clinical pharmacist; CYP2D6; CYP2D7P; CYP2D8P; copy number variation; CNV; genotyping; 5'nuclease assay; HRM; high resolution melting; drug metabolization; extracellular vesicles; exosomes; microvesicles; pharmacogene expression; medication review; deprescriptions; quality of life; aged; 80 and over; nursing homes; deprescribing; medication-based risk score; health outcomes; cytochromes; CYP1A2; adverse drug reaction; antipsychotics; olanzapine; clozapine; loxapine; children; youth; digital decision-support; health services research; general practice; process evaluation; antidepressants; utility; population-based; appropriateness; medication adherence; digital health
• Online Access: DOAB: download the publication; DOAB: description of the publication

Polypharmacy is a necessary and important aspect of drug treatment; however, it becomes a challenge when the medication risks outweigh the benefits for an individual patient. Drug-drug interactions and the introduction of prescribing cascades are common features of polypharmacy, which can lead to in...