Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches

• Other Authors: Danti, Serena (Editor), Negrini, Nicola Contessi (Editor), Franchi, Alessandro (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; Technology, engineering, agriculture; biomaterials; tissue engineering; 3D cell culture; cancer cells; bioprinting; breast cancer; metastasis; bone; 3D modeling; tumor microenvironment; extracellular matrix; 3D printing; 3D bioprinting; bone cancer; calcium phosphates; bone model; orthopedics; EGFR; trafficking; degradation; self-assembling peptides; 3D culture; pancreatic ductal adenocarcinoma; PDAC; drug resistance; 3D tumor model; 3D microfiber; amoeboid cell migration; brain cancer; PTEN; RHO; ROCK; durotaxis; topotaxis; pancreatic cancer; tumour microenvironment (TME); treatment resistance; radiotherapy; radiation; radioprotection; hypoxia; polyurethane scaffolds; extracellular matrix (ECM); HIF-1a; PANC-1; organoids; tumour heterogeneity; colorectal neoplasms; clonal evolution; longitudinal imaging; neoplasm recurrence; cell lineage; self-renewal; cell culture techniques; 3D cancer models; immunotherapies; tumor escape mechanisms; epithelial ovarian cancer; 3D in vitro model; chemotherapy; Cisplatin; spheroids; hydrogels; polymeric scaffolds; A2780; SK-OV-3; fused deposition modeling; cancer tissue engineering; in vitro model; mechanical properties; mesenchymal stromal cell; bone matrix; personalized therapy; scaffold; primary cancer cells; experimental models; screening; 3Rs; tumour modelling; polyhydroxyalkanoates (PHAs); colon cancer; epithelial-mesenchymal transition (EMT); scaffolds; 3D; three-dimensional; model; ovarian; cancer; patient-derived; personalised; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

This reprint focuses on fundamental and applied research involving the combination of biomaterials and cancer cells to develop a three-dimensional (3D) tumor microenvironment in vitro, in which carcinogenesis mechanisms can be studied and therapies can be screened. Such models are becoming quite popular within the bioengineering community; thus, many technologies are being tested to obtain the best scaffold for each tumor. In any case, only a tight interaction of bioengineers with cancer biologists and oncologists can make such 3D models progress, with them finally reaching a clinical relevance. On the other hand, the medical community is approaching simpler 3D in vitro models not provided with sufficient extracellular matrix biomimicry, such as spheroids and organoids, which may not be self-exhaustive; therefore, cancer researchers could benefit from closer contact with bioengineers. The aim of this reprint is to help generate shared knowledge and promote strong interdisciplinary collaboration with the ultimate goal of contributing to the acceleration of the discovery and validation of more precise therapies to fight cancer.

Physical Description

1 electronic resource (312 p.)

ISBN

books978-3-0365-6843-0
9783036568423
9783036568430

Access

Open Access