Pathogenesis and Targeted Therapy of Epilepsy

• Other Authors: N'Gouemo, Prosper (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Neurosciences; 3CAI; GRIA1; GRIA2; intractable epilepsy; PICK1; protein kinase C; pericytes; mural cells; cytokine; blood-brain barrier; neuroinflammation; 3-phosphoinositide-dependent protein kinase-1; AKT; cyclosporin A; GluA1; GluR1; PDK1; refractory seizure; temporal lobe epilepsy; hippocampus; 4-aminopyridine; epilepsy model; long-term potentiation; AMPA receptor; audiogenic epilepsy; rodents; fear reaction; behavior genetics; c-Fos; early gene activation; epileptogenesis; lipopolysaccharide; pentylenetetrazole; post-traumatic epilepsy; seizure susceptibility; traumatic brain injury; epilepsy; ghrelin; ghrelin receptor; anxiety; TRPV1 channels; neuronal activity; neuropsychiatric comorbidity; immunofluorescence; audiogenic kindling; acoustically evoked seizures; EACT; generalized tonic-clonic seizures; inherited epilepsy; TMEM1A channels; wild running seizures; astrocyte; ML365; pharmacoresistant epilepsy; cortical atrophy; hippocampal atrophy; intracerebral electrode; magnetic resonance imaging; posttraumatic epilepsy; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called "pharmaco-resistant epilepsy" or "refractory epilepsy." Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint's original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.

Physical Description

1 electronic resource (236 p.)

ISBN

books978-3-0365-6437-1
9783036564364
9783036564371

Access

Open Access