Advances in Diagnostic Dermatopathology, from Histopathologic to Molecular Studies

• Other Authors: Sakai, Yasuhiro (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; extramammary Paget's disease; dermcidin; prognosis; lymph node metastasis; survival; mechanical intermittent compression; malignant melanoma; in vitro model; cancer progression; mycosis fungoides; early stage; diagnostic algorithm; T-cell receptor rearrangement; tumor-specific marker; microRNA; keratoacanthoma; squamous cell carcinoma (SCC); keratoacanthoma-like SCC; keratoacanthoma with malignant transformation; crateriform neoplasms; crateriform verruca; crateriform seborrheic keratosis; crateriform Bowen disease; crateriform SCC arising from actinic keratosis; crater form of infundibular SCC; psoriasis; STAT3; cancer; immunohistochemistry; atopic dermatitis; biologic agents; neuroimmune interactions; type 2 inflammation; PSORS1C3; PSORS1C1/CDSN; LOC105375015; rs1062470; rs887466; rs10484554; single-nucleotide polymorphism; epidermolysis bullosa; mutation; heterogeneity; nevus sebaceus; malignant tumor; basal cell carcinoma; sebaceus carcinoma; lichen sclerosus; extracellular matrix protein 1; lipoid proteinosis; basement membrane zone; laminin-332; collagen IV; collagen VII; glycosaminoglycan; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

This reprint focuses on novel findings of diagnostic dermatopathology, such as diagnosable new morphological (histopathologic) findings, immunohistochemical and immunofluorescent markers, and molecular techniques. Dermatopathology is the most sophisticated area in anatomic pathology; we can easily observe superficial skin lesions using our eyes without the need for an invasive approach and can easily compare gross configurations to microscopic and immunohistochemical findings. Meanwhile, dermatopathology has recently focused on the study of various cutaneous diseases at the molecular biology level. Many cutaneous diseases are now being well-researched, and special attention is paid to keratoacanthoma, lichen sclerosus (et atrophicus), mycosis fungoides, atopic dermatitis, epidermolysis bullosa, extramammary Paget's disease, malignant melanoma, psoriasis, and secondary neoplasms associated with nevus sebaceous.