Human Papillomavirus and Head and Neck Cancer

• Other Authors: Walline, Heather (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Oncology; head and neck cancer; human papillomavirus; oropharyngeal cancer; virus-related cancers; human papillomavirus diagnosis; sinonasal squamous cell carcinoma; prevalence; detection method; anatomic subsite; photodynamic therapy; ER/mitochondrial photosensitizer; paraptosis; apoptosis; autophagy; HPV; OPSCC; tonsillar cancer; survival; OS; DFS; p16; recurrence; cancer subtypes; gene expression; oropharynx; HPV integration; immune response; keratinization; TATI; Human Papillomavirus (HPV); immune status; hematological parameters; radiotherapy; oropharyngeal squamous cell carcinoma; DNA methylation; transposable elements; overall survival; head and neck squamous cell carcinoma; extracellular vesicle; proteomic; oropharyngeal cancer (OPC); human papillomavirus (HPV); cancer stem cells (CSCs); CSC markers; prognosis; tumor heterogeneity; positron emission tomography; diffusion-weighted; dynamic contrast-enhanced; kinetic modeling; fast exchange regime model; community detection algorithm; spin-glass model; high-risk human papillomaviruses; head and neck squamous cell carcinomas; viral DNA integration; PCR; DIPS-PCR; APOT-PCR; WGS; WES; capture-based assay; RNASeq; FISH; consequences of HPV integration; p53; cancer; glycolysis; oxidative phosphorylation; metabolism; biomarkers; staging; TNM; prognostic; T regulatory lymphocytes; FoxP3; Langerhans cells; CD1a; immune cells
• Online Access: DOAB: download the publication; DOAB: description of the publication

In the study of head and neck squamous cell carcinoma (HNSCC), we know that virally induced malignancies behave differently than those generated through other carcinogenic mechanisms. This paradigm extends into differences in tumor growth, treatment response and resistance, as well as invasion and metastasis. The inability to correctly diagnose and appropriately treat HNSCC at early stages has contributed to reduced survival for HNSCC patients, particularly those with HPV-negative disease. The examination of the molecular differences between HPV-positive and HPV-negative HNSCC will provide support for early diagnostic markers and guide appropriate treatment selection to improve patient care and survival.This Special Issue highlights current research efforts to understand the evolving contribution of human papillomavirus in HNSCC.