A Commemorative Issue in Honor of Centennial of the Discovery of Vitamin D-The Central Role of Vitamin D in Physiology

• Other Authors: Carlberg, Carsten (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; Physiology; vitamin D; VDR; target genes; chromatin; epigenome; transcriptome; vitamin D signaling; 25-hydroxyvitamin D; 1,25-(OH)2D3; antitumor action; breast cancer; case-control studies; colorectal cancer; cohort studies; ecological studies; epidemiological studies; randomized controlled trials; UVB; vitamin D receptor; 3D structure; structural analysis; molecular recognition; protein-ligand interactions; coregulators; acute myeloid leukemia; blast; 1,25-dihydroxyvitamin D; analogs; all-trans-retinoic acid; differentiation; immunomodulation; evolution; energy metabolism; immune system; calcium homeostasis; migration of Homo sapiens; influenza; SARS-CoV-2; lung; inflammation; infantile hypercalcemia type 1; idiopathic infantile hypercalcemia; CYP24A1; 25-hydroxyvitamin D 24-hydroxylase; hypercalcemia; 24,25-dihydroxyvitamin D3; fracture repair; diet; transcellular; absorption; diffusion; intestine; homeostasis; parathyroid hormone; gestational diabetes; preeclampsia; preterm birth; ovarian cancer; vitamin D analogs; vitamin D deficiency; single high dose; vitamin D3 supplementation; proinflammatory cytokines; IL6; IL8; TNF; 25(OH)D3; brain; development; neuroprotection; disease mechanisms; genetic risk; heritability; personalized supplementation; genome-wide association study; Mendelian randomization; lumisterol; anti-inflammatory; ACE2; Mpro; RdRp; month of birth; muscle; pregnancy; older adults; metabolites; hybrids and VDR nonsecosteroidal ligands; nongenomic response; PDIA3; ultraviolet radiation; megalin; mitochondria; vitamin D metabolism; fibroblast growth factor-23; klotho; 1α-hydroxylase; RAAS; systems biology; cell differentiation; prostate cancer; n/a; bone; osteoblasts; differentiation and mineralization; McCollum; sunlight; rickets; food fortification; vitamin D2; vitamin D3; COVID-19
• Online Access: DOAB: download the publication; DOAB: description of the publication

This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as...