Molecular Mechanisms of Steroid Hormone Biosynthesis and Action

• Other Authors: Tremblay, Jacques J. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Medicine; steroidogenesis; testis; transcription; testosterone; Leydig cell; GATA; cholesterol; cholesterol transport; steroidogenic acute regulatory protein; sterol carrier protein 2; sterol carrier protein-x; MnHR4; 20-hydroxyecdysone (20E); Macrobrachium nipponense; molt; RNA interference; Leydig cells; star; AMPK; phosphoproteomics; proteomics; activator protein 1; CREB; CEBPB; Steroidogenesis; signaling cascade; Nuclear receptors; bZIP factors; MEF2 factors; GATA4; CAMKI; PKA; ERK1/2; Hippo signaling; Lats1/2; fetal Leydig cells; Sertoli cells; transgenic mouse model; ovary; cow; Hippo; follicle deviation or divergence; yes-associated protein 1; CTGF; CYR61; ANKRD1; transgenic mice; adrenal cortex; development; maintenance; glucocorticoid receptor; androgens; leydig cells; AAV9; insulin-like 3; transcription factors; linker-scanning mutagenesis; DNA-protein interactions; bile acids; TGR5; cholesterol esters; LH; LH-receptor; spermatogenesis; thrombospondin-2; NR5A1; enhancer; pituitary gonadotrope; luteinizing hormone; follicle-stimulating hormone; 11-oxygenated androgens; steroid hormones; LC-MS/MS; method validation; adrenocortical carcinoma; histone deacetylase inhibitor; cell differentiation; gene expression; adrenal gland inner cortex; X-zone; DHCR24; seladin-1; endocrine disruptors; EDC mixtures; in utero exposures; transcriptome analysis; testicular function; aldo-keto reductase; bile acid; deficiency; congenital adrenal hyperplasia; hydroxysteroid dehydrogenase; prostate cancer; single nucleotide polymorphism; structure-function; steroid reductase; pseudohermaphroditism
• Online Access: DOAB: download the publication; DOAB: description of the publication

Steroids are essential hormones that regulate biological processes across their lifespan. Steroid hormone production and action must be tightly controlled otherwise there can be detrimental effects on physiological function leading to disease. This reprint contains original and review articles by experts at the cutting edge of their fields published in a Special Issue on the "Molecular mechanisms of steroid hormone biosynthesis and action" of the International Journal of Molecular Sciences. The topics include: 1) Steroid hormone biosynthesis, including substrate availability, mechanism of steroidogenic enzyme action, and the impact of mutations; 2) Molecular and cellular regulation of steroidogenesis, including steroidogenic cell response to hormone stimulation, signaling pathways, kinases, transcription factors, and gene expression; 3) Molecular mechanisms of endocrine disruptor action on steroidogenic cells; and 4) New tools and approaches to detect and study steroid hormones.