Addressing New Therapeutic Strategies Using Models

• Other Authors: Faustino, Ana (Editor), Oliveira, Paula A. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: Research & information: general; Biology, life sciences; spontaneous models; induced models; genetically engineered models; acute kidney injury; biomarkers; coagulation; ischemia-reperfusion injury; shock; newborn lamb; multiple intestinal loop model; 3R; Cryptosporidium parvum; yeast cell wall fractions; fatty liver disease; glucose; imipramine; insulin; obesity; renal impairment; retinal injury; xenograft; ectopic; orthotopic; hIBC; cIMC; whole-body ischemia; cardiopulmonary resuscitation; drug-induced hypothermia; spinal motor neuron; inflammation; paraplegia; virucidal drugs; IBV; chickens; Coronaviridae; silver nanoparticles; artificial ribonuclease; monoglyceride lauryl acid; spinal cord hemisection; Macaca radiata; predegenerated nerve transplantation; locomotor recovery; Cornu Ammonis 1; glutaminergic synapse; memory function; oligodendrocyte; pyramidal cells; animal model; trichotillomania; hair-pulling; body-focused repetitive disorder; transitional cell carcinoma; urothelial carcinoma; histology; therapeutic marker; prognosis; mandibular growth; mandibular posterior displacement; mandibular length; condylar growth; rat; class III malocclusion; orthodontic treatment; antebrachial growth deformity; dog; osteotomy; patient-specific instrumentation; 3-D; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

A disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, establishing the pathophysiology of a disease, and testing potential therapeutic approaches.Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today.This Special Issue aimed to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies.