IL-27 Activates Human Trophoblasts to Express IP-10 and IL-6: Implications in the Immunopathophysiology of Preeclampsia

• Main Authors: Nanlin Yin (Author), Hua Zhang (Author), Xin Luo (Author), Yubin Ding (Author), Xiaoqiu Xiao (Author), Xiru Liu (Author), Nan Shan (Author), Xuemei Zhang (Author), Qinyin Deng (Author), Baimei Zhuang (Author), Hongbo Qi (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. To investigate the effects of IL-27 on human trophoblasts and the underlying regulatory signaling mechanisms in preeclampsia. Methods. The expression of IL-27 and IL-27 receptor (WSX-1) was studied in the placenta or sera from patients with preeclampsia. In vitro, we investigated the effect...