Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.

• Päätekijät: Beatriz Álvarez-Rodríguez (Tekijä), Christian Tiede (Tekijä), Alexis C R Hoste (Tekijä), Rebecca A Surtees (Tekijä), Chi H Trinh (Tekijä), Gillian S Slack (Tekijä), John Chamberlain (Tekijä), Roger Hewson (Tekijä), Alba Fresco (Tekijä), Patricia Sastre (Tekijä), Darren C Tomlinson (Tekijä), Paul A Millner (Tekijä), Thomas A Edwards (Tekijä), John N Barr (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Public Library of Science (PLoS), 2020-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleopr...