Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

• Main Authors: Tara Jois (Author), Weiyi Chen (Author), Victor Howard (Author), Rebecca Harvey (Author), Kristina Youngs (Author), Claudia Thalmann (Author), Pradip Saha (Author), Lawrence Chan (Author), Michael A. Cowley (Author), Mark W. Sleeman (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Carbohydrate response element binding protein (ChREBP) is a transcription factor that responds to glucose and activates genes involved in the glycolytic and lipogenic pathways. Recent studies have linked adipose ChREBP to insulin sensitivity in mice. However, while ChREBP is most highly e...