Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice

• Main Authors: Ida Tomomi (Author), Hiroyuki Kanzaki (Author), Miho Shimoyama (Author), Syunnosuke Tohyama (Author), Misao Ishikawa (Author), Yuta Katsumata (Author), Chihiro Arai (Author), Satoshi Wada (Author), Shugo Manase (Author), Hiroshi Tomonari (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcification plays a key role in biological processes, and breakdown of the regulatory mechanism results in a pathological state such as ectopic calcification. We hypothesized that ENPP1, the enzyme that produces the calcification inhibitor pyrophosphate, is transcriptionally regulated by Nrf2, and...