Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation

• Main Authors: Mythili Dileepan (Author), Stephanie Rastle-Simpson (Author), Yana Greenberg (Author), Dayanjan S. Wijesinghe (Author), Naren Gajenthra Kumar (Author), Jun Yang (Author), Sung Hee Hwang (Author), Bruce D. Hammock (Author), P. Sriramarao (Author), Savita P. Rao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arachidonic acid metabolites resulting from the cyclooxygenase (COX), lipoxygenase, and cytochrome P450 oxidase enzymatic pathways play pro- and anti-inflammatory roles in allergic airway inflammation (AAI) and asthma. Expression of COX-2 and soluble epoxide hydrolase (sEH) are elevated in allergic...