Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

• Автори: Andrea Calcaterra (Автор), Valentina Iovine (Автор), Bruno Botta (Автор), Deborah Quaglio (Автор), Ilaria D'Acquarica (Автор), Alessia Ciogli (Автор), Antonia Iazzetti (Автор), Romina Alfonsi (Автор), Ludovica Lospinoso Severini (Автор), Paola Infante (Автор), Lucia Di Marcotullio (Автор), Mattia Mori (Автор), Francesca Ghirga (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the chemical nature of its bioactive form. GANT61 is...