Autophagy increase in Merosin-Deficient Congenital Muscular Dystrophy type 1A

• Main Authors: Mariangela Mastrapasqua (Author), Roberta Rossi (Author), Lucrezia De Cosmo (Author), Annalisa Resta (Author), Mariella Errede (Author), Antonella Bizzoca (Author), Stefania Zampatti (Author), Nicoletta Resta (Author), Emiliano Giardina (Author), Maddalena Ruggieri (Author), Daniela Virgintino (Author), Tiziana Annese (Author), Nicola Laforgia (Author), Francesco Girolamo (Author)
• Format: Book
• Published: PAGEPress Publications, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The autophagy process recycles dysfunctional cellular components and protein aggregates by sequestering them in autophagosomes directed to lysosomes for enzymatic degradation. A basal level of autophagy is essential for skeletal muscle maintenance. Increased autophagy occurs in several forms of musc...