Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia

• Main Authors: Jie Gao (Author), Michael Van Meter (Author), Susana Hernandez Lopez (Author), Guoying Chen (Author), Ying Huang (Author), Shumei Ren (Author), Qi Zhao (Author), Jose Rojas (Author), Cagan Gurer (Author), Gavin Thurston (Author), Frank Kuhnert (Author)
• Format: Book
• Published: The Company of Biologists, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer derived from the malignant transformation of T-cell progenitors. Outcomes remain poor for T-ALL patients who have either primary resistance to standard-of-care chemotherapy or disease relapse. Notably, there are currentl...