Cover Image

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) progression. RAW264.7 macrophages were polarized to M1/M2 subtypes then administered with different concentrations...

Full description

Saved in:

Bibliographic Details
Main Authors:	Feng Zhou (Author), Jingtian Mei (Author), Xiuguo Han (Author), Hanjun Li (Author), Shengbing Yang (Author), Minqi Wang (Author), Linyang Chu (Author), Han Qiao (Author), Tingting Tang (Author)
Format:	Book
Published:	Elsevier, 2019-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway
by: Minjun Yao, et al.
Published: (2022)

Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways
by: Fang Xu, et al.
Published: (2022)

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
by: Ran J, et al.
Published: (2018)

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts
by: Meisong Zhu, et al.
Published: (2022)

Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis
by: Huangming Zhuang, et al.
Published: (2023)

CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-κB pathway
by: Weilu Gao, et al.
Published: (2024)

Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways
by: Yao-Xin Gao, et al.
Published: (2018)

Kinsenoside Ameliorates Oxidative Stress-Induced RPE Cell Apoptosis and Inhibits Angiogenesis via Erk/p38/NF-κB/VEGF Signaling
by: Xu Luo, et al.
Published: (2018)

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice
by: Zeng Lin, et al.
Published: (2019)

Iridoid glycosides from Morinda officinalis How. exert anti-inflammatory and anti-arthritic effects through inactivating MAPK and NF-κB signaling pathways
by: Qi Zhang, et al.
Published: (2020)

Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway
by: Zhixian Xu, et al.
Published: (2021)

Tamarixetin Protects Chondrocytes against IL-1β-Induced Osteoarthritis Phenotype by Inhibiting NF-κB and Activating Nrf2 Signaling
by: Seung-Ho Lee, et al.
Published: (2024)

Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
by: Chenghao Ren, et al.
Published: (2021)

Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes
by: Chang Tu, et al.
Published: (2019)

Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway
by: Hongbo You, et al.
Published: (2021)

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
by: Sheng-long Ding, et al.
Published: (2020)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
by: Zengxin Jiang, et al.
Published: (2022)

Icariin Activates Autophagy via Down-Regulation of the NF-κB Signaling-Mediated Apoptosis in Chondrocytes
by: Bobin Mi, et al.
Published: (2018)

Embelin Induces Apoptosis in Human Glioma Cells Through Inactivating NF-κB
by: Sang-Yoon Park, et al.
Published: (2013)

Safflower Seed Extract Attenuates the Development of Osteoarthritis by Blocking NF-κB Signaling
by: Seong Jae Han, et al.
Published: (2021)

Schisandrol A Suppresses Catabolic Factor Expression by Blocking NF-κB Signaling in Osteoarthritis
by: Seong Jae Han, et al.
Published: (2021)

Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway
by: Xin Lv, et al.
Published: (2021)

Valsartan attenuates LPS-induced ALI by modulating NF-κB and MAPK pathways
by: Mi Zhou, et al.
Published: (2024)

DMSO Alleviates LPS-Induced Inflammatory Responses in RAW264.7 Macrophages by Inhibiting NF-κB and MAPK Activation
by: Hyunju Han, et al.
Published: (2023)

Morroniside Inhibits Inflammatory Bone Loss through the TRAF6-Mediated NF-κB/MAPK Signalling Pathway
by: Jirimutu Xiao, et al.
Published: (2023)

Amphiregulin Induces iNOS and COX-2 Expression through NF-κB and MAPK Signaling in Hepatic Inflammation
by: Yu Jung Heo, et al.
Published: (2023)

Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes
by: Haijun Zhao, et al.
Published: (2021)

BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes
by: Honggang Xu, et al.
Published: (2021)

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway
by: Yiping Mu, et al.
Published: (2022)

Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-κB signaling
by: Michael A. Ortega, et al.
Published: (2022)

Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-κB in rats with trigeminal neuropathic pain
by: Lee Min K, et al.
Published: (2011)

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
by: Jia Y, et al.
Published: (2020)

α-Chaconine Facilitates Chondrocyte Pyroptosis and Nerve Ingrowth to Aggravate Osteoarthritis Progression by Activating NF-κB Signaling
by: Zhang Z, et al.
Published: (2022)

Acacetin inhibits inflammation by blocking MAPK/NF-κB pathways and NLRP3 inflammasome activation
by: Juan Bu, et al.
Published: (2024)

<i>Artemisia gmelinii</i> Attenuates Lung Inflammation by Suppressing the NF-κB/MAPK Pathway
by: Seung Yong Kim, et al.
Published: (2022)

Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways
by: Yue Miao, et al.
Published: (2024)

Tamarixinin A Alleviates Joint Destruction of Rheumatoid Arthritis by Blockade of MAPK and NF-κB Activation
by: Yuanyuan Zhuang, et al.
Published: (2017)

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways
by: Wei Wang, et al.
Published: (2020)

The mechanism of nicotinamide on reducing acute lung injury by inhibiting MAPK and NF-κB signal pathway
by: Qun Zhang, et al.
Published: (2021)

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB
by: Xia Huang, et al.
Published: (2017)