The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study

• Main Authors: Michael S. Tanner (Author), Deborah De Guingand (Author), Maya Reddy (Author), Saskia Rowson (Author), Daniel L. Rolnik (Author), Fabricio Da Silva Costa (Author), Mary-Ann Davey (Author), Ben W. Mol (Author), Euan M. Wallace (Author), Kirsten R. Palmer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1064-1955; 1525-6065; 10.1080/10641955.2021.1991371
• Keywords: preeclampsia; hypertension; angiogenic; complications; comorbidities; Gynecology and obstetrics; RG1-991
• Source: Hypertension in Pregnancy, Vol 40, Iss 4, Pp 336-345 (2021)

Objective:To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia. Methods: A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes. Results:We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications. Conclusion: Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.