Clinic presentation delay and tuberculosis treatment outcomes in the Lake Victoria region of East Africa: A multi-site prospective cohort study
In the Lake Victoria region of East Africa, little is known about delays between tuberculosis (TB) symptom onset and presentation at a clinic. Associations between clinic presentation delay and TB treatment outcomes are also poorly understood. In 2019, we abstracted data from routine TB treatment re...
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Public Library of Science (PLoS),
2023-01-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_01a3f5044ddc41b88cd7b9ea1d7a377f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Grace E. Mulholland |e author |
| 700 | 1 | 0 | |a Michael E. Herce |e author |
| 700 | 1 | 0 | |a Brenda A. Okech |e author |
| 700 | 1 | 0 | |a Kidola Jeremiah |e author |
| 700 | 1 | 0 | |a Ubaldo M. Bahemuka |e author |
| 700 | 1 | 0 | |a Zachary A. Kwena |e author |
| 700 | 1 | 0 | |a Gertrude Nanyonjo |e author |
| 700 | 1 | 0 | |a Janet Seeley |e author |
| 700 | 1 | 0 | |a Audrey Pettifor |e author |
| 700 | 1 | 0 | |a Michael Emch |e author |
| 700 | 1 | 0 | |a Sharon S. Weir |e author |
| 700 | 1 | 0 | |a Jessie K. Edwards |e author |
| 245 | 0 | 0 | |a Clinic presentation delay and tuberculosis treatment outcomes in the Lake Victoria region of East Africa: A multi-site prospective cohort study |
| 260 | |b Public Library of Science (PLoS), |c 2023-01-01T00:00:00Z. | ||
| 500 | |a 2767-3375 | ||
| 520 | |a In the Lake Victoria region of East Africa, little is known about delays between tuberculosis (TB) symptom onset and presentation at a clinic. Associations between clinic presentation delay and TB treatment outcomes are also poorly understood. In 2019, we abstracted data from routine TB treatment records for all adults (n = 776) initiating TB treatment in a 6-month period across 12 health facilities near Lake Victoria. We interviewed 301 cohort members and assessed whether they experienced a clinic presentation delay longer than 6 weeks. We investigated potential clinical and demographic correlates of clinic presentation delay and examined the association between clinic presentation delay and an unfavorable TB treatment outcome (death, loss to follow-up, or treatment failure). Clinic presentation delay was common, occurring among an estimated 54.7% (95% CI: 48.9%, 61.2%) of cohort members, though no specific correlates were identified. Clinic presentation delay was slightly associated with unfavorable TB treatment outcomes. The 180-day risk of an unfavorable outcome was 14.2% (95% CI: 8.0%, 20.4%) among those with clinic presentation delay, compared to 12.7% (95% CI: 5.1%, 20.3%) among those presenting earlier. Multi-level community-based interventions may be necessary to reduce clinic presentation delays in communities near Lake Victoria. | ||
| 546 | |a EN | ||
| 690 | |a Public aspects of medicine | ||
| 690 | |a RA1-1270 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n PLOS Global Public Health, Vol 3, Iss 8 (2023) | |
| 787 | 0 | |n https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468066/?tool=EBI | |
| 787 | 0 | |n https://doaj.org/toc/2767-3375 | |
| 856 | 4 | 1 | |u https://doaj.org/article/01a3f5044ddc41b88cd7b9ea1d7a377f |z Connect to this object online. |