UNILATERAL PROFOUND DEAFNESS - A POSSIBLE MECHANISM

• Auteurs principaux: Konstantin Georgiev (Auteur), Yana Pacholova (Auteur)
• Format: Livre
• Publié: Peytchinski Publishing, 2021-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.
• Notes: 10.5272/jimab.2021273.3829; 1312-773X
• Keywords: unilateral sensorineural hearing loss; tectorial membrane; hair cells; Dentistry; RK1-715; Medicine (General); R5-920
• Source: Journal of IMAB, Vol 27, Iss 3, Pp 3829-3834 (2021)

Purpose: To explain the clinical findings of patients with profound unilateral deafness who have recovered the hearing function after a combined treatment of hyperbaric oxygenation and dehydrant therapy. Material and method: 11 patients with profound sudden unilateral hearing loss above 90 dB SPL, intolerance to sounds similar to recruitment, at levels 10-20 dB above the hearing threshold (105-120 dB SPL), positive glycerol test and unexpected good recovery of hearing within 1-2 months are described. Results: All patients have perfect outcome results without the use of glucocorticoids. Conclusions: Based on articles about experiments with genetically modified animals and acquired deafness, we propose a possible mechanism of damage explaining the clinical findings and the favorable outcome of the disease - a disconnection between the tectorial membrane and stereocilia. Thus mechano-electrical transducer (MET) of hair cells cannot be activated. The combined use of hyperbaric oxygenation and dehydrant medications can lead to recovery of the hearing function.