Characterization of large volume subcutaneous injections using computed tomography imaging and simultaneous pressure measurements

• Main Authors: Mona Purcell (Author), Sahab Babaee (Author), Michael Galluppi (Author), John Cline (Author), Guangli Hu (Author), Ioan Petrescu (Author), Jennifer Hughes (Author), Meredith Allen (Author), Eric Messina (Author), Steven Persak (Author), Yogita Krishnamachari (Author), Ashley Lay-Fortenbery (Author), Corin O. Miller (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many commercially available biologics, previously delivered only intravenously, are being re-formulated for subcutaneous delivery to improve patient access and compliance. However, due to inherent solubility limitations, large volume injections (more than 2 mL) are typically required. Different stra...